ModLS: Post-Translational Modification Localization Scoring with Automatic Specificity Expansion
نویسندگان
چکیده
منابع مشابه
Allosteric post-translational modification codes.
Post-translational modifications (PTMs) have been recognized to impact protein function in two ways: (i) orthosterically, via direct recognition by protein domains or through interference with binding; and (ii) allosterically, via conformational changes induced at the functional sites. Because different chemical types of PTMs elicit different structural alterations, the effects of combinatorial...
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Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes. SUMOylation is another PTM known to modify a large number of proteins and plays a role in various cellular processes including: cell cycle ...
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A new global post-translational modification (PTM) discovery strategy, G-PTM-D, is described. A proteomics database containing UniProt-curated PTM information is supplemented with potential new modification types and sites discovered from a first-round search of mass spectrometry data with ultrawide precursor mass tolerance. A second-round search employing the supplemented database conducted wi...
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Introduction Covalently attached prosthetic groups serve as swinging arms in several different and wellcharacterized multifunctional enzymes. Notable among these are the lipoyl-lysine residues in 2-0x0 acid dehydrogenase multienzyme complexes [l-31 and the glycine cleavage system [4-61, the biotinyl-lysine residues in various ATP-dependent carboxylases [7,8] and the phosphopantetheinyl-serine r...
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ژورنال
عنوان ژورنال: Journal of Proteomics & Bioinformatics
سال: 2012
ISSN: 0974-276X
DOI: 10.4172/jpb.1000251